Article
Lincomycin-Induced Secondary Metabolism in Streptomyces lividans 66 with a Mutation in the Gene Encoding the RNA Polymerase Beta Subunit.
Current microbiology - 1 Oct 2020
Mukai Keiichiro, Kobayashi Momoko, Hoshino Kanata, Maruyama Tomoko, Hayashi Daiki, Hamauzu Ryoko, Hosaka Takeshi
Abstract excerpt
Activating the genetic potential of Streptomyces strains to produce secondary metabolites can improve the production of useful biologically active compounds and facilitate the discovery of novel biologically active compounds. In this study, we found that Streptomyces lividans carrying the R440H mutation in rpoB, encoding the RNA polymerase beta subunit, grown in the presence of lincomycin at concentrations below...
Topics
- Anti-Bacterial Agents
- DNA-Directed RNA Polymerases
- Lincomycin
- Mutation
- Secondary Metabolism
- Streptomyces lividans