The complete 12 Mb genome and transcriptome of Nonomuraea gerenzanensis with new insights into its duplicated "magic" RNA polymerase.

doi:10.1038/s41598-016-0025-0

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The complete 12 Mb genome and transcriptome of Nonomuraea gerenzanensis with new insights into its duplicated "magic" RNA polymerase.

Scientific reports - 21 Dec 2016

D'Argenio Valeria, Petrillo Mauro, Pasanisi Daniela, Pagliarulo Caterina, Colicchio Roberta, Talà Adelfia, de Biase Maria Stella, Zanfardino Mario, Scolamiero Emanuela, Pagliuca Chiara, Gaballo Antonio, Cicatiello Annunziata Gaetana, Cantiello Piergiuseppe, Postiglione Irene, Naso Barbara, Boccia Angelo, Durante Miriana, Cozzuto Luca, Salvatore Paola, Paolella Giovanni, Salvatore Francesco, Alifano Pietro

Abstract excerpt

In contrast to the widely accepted consensus of the existence of a single RNA polymerase in bacteria, several actinomycetes have been recently shown to possess two forms of RNA polymerases due the to co-existence of two rpoB paralogs in their genome. However, the biological significance of the rpoB duplication is obscure. In this study we have determined the genome sequence of the lipoglycopeptide antibiotic...

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PMID: 28442708
DOI: 10.1038/s41598-016-0025-0
PMCID: PMC5431353

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