Article
Adaptive Resistance Mutations at Suprainhibitory Concentrations Independent of SOS Mutagenesis.
Molecular biology and evolution - 27 Sept 2021
Gutiérrez Ricardo, Ram Yoav, Berman Judith, de Sousa Keyla Carstens Marques, Nachum-Biala Yaarit, Britzi Malka, Elad Daniel, Glaser Gad, Covo Shay, Harrus Shimon
Abstract excerpt
Emergence of resistant bacteria during antimicrobial treatment is one of the most critical and universal health threats. It is known that several stress-induced mutagenesis and heteroresistance mechanisms can enhance microbial adaptation to antibiotics. Here, we demonstrate that the pathogen Bartonella can undergo stress-induced mutagenesis despite the fact it lacks error-prone polymerases, the rpoS gene and...
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