Article
An RpoB mutation confers dual heteroresistance to daptomycin and vancomycin in Staphylococcus aureus.
Antimicrobial agents and chemotherapy - 1 Dec 2010
Cui Longzhu, Isii Taisuke, Fukuda Minoru, Ochiai Tomonori, Neoh Hui-Min, Camargo Ilana Lopes Baratella da Cunha, Watanabe Yukiko, Shoji Mitsutaka, Hishinuma Tomomi, Hiramatsu Keiichi
Abstract excerpt
We have previously reported the establishment of a Staphylococcus aureus laboratory strain, 10 3d1, having reduced susceptibility to daptomycin and heterogeneous vancomycin-intermediate S. aureus (VISA) phenotype. The strain was generated in vitro by serial daptomycin selection (Camargo, I. L., H. M. Neoh, L. Cui, and K. Hiramatsu, Antimicrob. Agents Chemother. 52:4289-4299, 2008). Here we explored the genetic...
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