Article
c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha.
Molecular and cellular biology - 1 Feb 2005
Srinivas Harish, Juroske Denise M, Kalyankrishna Shailaja, Cody Dianna D, Price Roger E, Xu Xiao-Chun, Narayanan Ramesh, Weigel Nancy L, Kurie Jonathan M
Abstract excerpt
Retinoic acid (RA) is the ligand for nuclear RA receptors (RARs and RXRs) and is crucial for normal epithelial cell growth and differentiation. During malignant transformation, human bronchial epithelial cells acquire a block in retinoid signaling caused in part by a transcriptional defect in RARs. Here, we show that activation of c-Jun N-terminal kinase (JNK) contributes to RAR dysfunction by phosphorylating...
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