Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RARgamma acts as a tumor suppressor in mouse keratinocytes.

Oncogene - 8 Jul 2004

Chen Chang Feng, Goyette Philippe, Lohnes David

Abstract excerpt

All-trans retinoic acid (RA), the principle biologically active form of vitamin A, is essential for many developmental process as well as homeostasis in the adult. Many lines of evidence also suggest that RA, acting through the RA receptors (RARs), can also suppress growth of tumors of diverse origin. To assess directly the role of the RARs in a model of epidermal tumorigenesis, we investigated the incidence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ras Proteins
Share to COS Cells
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Keratinocytes

Share to Receptors, Retinoic Acid

Share to Retroviridae

Share to Tretinoin

Source

Identifiers

PMID: 15094780
DOI: 10.1038/sj.onc.1207682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RARgamma acts as a tumor suppressor in mouse keratinocytes.PMID 15094780Read ↗

A PMLRARA transgene results in a retinoid-deficient phenotype associated with enhanced susceptibility to skin tumorigenesis.Semantic proximity Read ↗

Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled.Semantic proximity Read ↗

Impaired cervical homeostasis upon selective ablation of RXRalpha in epithelial cells.Semantic proximity Read ↗

Specific activation of retinoic acid receptors (RARs) and retinoid X receptors reveals a unique role for RARgamma in induction of differentiation and apoptosis of S91 melanoma cells.Semantic proximity Read ↗

Dominant-negative retinoic acid receptors elicit epidermal defects through a non-canonical pathway.Semantic proximity Read ↗

A Novel Role of RASSF9 in Maintaining Epidermal HomeostasisSemantic proximity Read ↗

Defects in transforming growth factor-β signaling cooperate with a <i>Ras</i> oncogene to cause rapid aneuploidy and malignant transformation of mouse keratinocytesSemantic proximity Read ↗

Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosisSemantic proximity Read ↗

GPRC5A deficiency leads to dysregulated MDM2 via activated EGFR signaling for lung tumor developmentSemantic proximity Read ↗

Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor.Semantic proximity Read ↗

Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis.Semantic proximity Read ↗

Identification of the retinoic acid-inducible Gprc5a as a new lung tumor suppressor gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.