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Article

Role of JNK in Tumor Development

29 May 2003

Abstract excerpt

The c-Jun NH2-terminal kinase (JNK) is implicated in oncogenic transformation. However, studies of the effect of Jnk gene disruption on Ras-induced transformation of murine fibroblasts indicate that JNK may act as a suppressor of Ras transformation and that the JNK signaling pathway contributes to the apoptotic elimination of transformed cells in vivo. The conclusion that JNK can act as a tumor suppressor is...

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Identifiers

PMID: 12734425
DOI: 10.4161/cc.2.3.388

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Source receipt: pubmed, retrieved 7 Sept 2026.

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