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Article

c-Jun N-terminal kinase negatively regulates dsRNA and RSV induction of tumor necrosis factor- alpha transcription in human epithelial cells.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Aug 2006

Stewart Michael J, Kulkarni Sandhya B, Meusel Tiffany R, Imani Farhad

Abstract excerpt

Secretion of inflammatory cytokines is the initial step of the immune response to viral infections. This innate immune response is mediated by the expression of a variety of cytokines, exemplified by tumor necrosis factor- alpha (TNF-alpha). The presence of dsRNA during viral infections is a key step in activation of several signaling pathways, including protein kinase R (PKR), toll-like receptor 3 (TLR3),...

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Source

Identifiers

PMID: 16881863
DOI: 10.1089/jir.2006.26.521

Genes

TNF
TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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