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A rat model of slow Wallerian degeneration (<i>Wld</i><sup><i>S</i></sup>) with improved preservation of neuromuscular synapses

1 Jan 2005

Abstract excerpt

The slow Wallerian degeneration phenotype, Wld(S), which delays Wallerian degeneration and axon pathology for several weeks, has so far been studied only in mice. A rat model would have several advantages. First, rats model some human disorders better than mice. Second, the larger body size of rats facilitates more complex surgical manipulations. Third, rats provide a greater yield of tissue for primary culture...

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PMID: 15654865
DOI: 10.1111/j.1460-9568.2004.03833.x

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