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Article

Polyglutamine expansion of huntingtin impairs its nuclear export.

Nature genetics - 1 Feb 2005

Cornett Jonathan, Cao Fengli, Wang Chuan-En, Ross Christopher A, Bates Gillian P, Li Shi-Hua, Li Xiao-Jiang

Abstract excerpt

Proteins with polyglutamine (polyQ) expansions accumulate in the nucleus and affect gene expression. The mechanism by which mutant huntingtin (htt) accumulates intranuclearly is not known; wild-type htt, a 350-kDa protein of unknown function, is normally found in the cytoplasm. N-terminal fragments of mutant htt, which contain a polyQ expansion (>37 glutamines), have no conserved nuclear localization sequences or...

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PMID: 15654337
DOI: 10.1038/ng1503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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