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Article

Essential sequence of the N-terminal cytoplasmic localization-related domain of huntingtin and its effect on huntingtin aggregates.

Science China. Life sciences - 1 Apr 2011

Yan Yaping, Peng Dantao, Tian Jun, Chi Jingwei, Tan Jieqiong, Yin Xinzhen, Pu Jiali, Xia Kun, Zhang Baorong

Abstract excerpt

Huntington's disease (HD) is caused by abnormal CAG repeat expansion in the 5'-end of the Huntingtin (HTT) gene. In addition to the canonical C-terminal full-length huntingtin (htt) nuclear export signal, a cytoplasmic localization-related domain (CLRD) in the N-terminus of htt has recently been reported. Here, we analyzed this domain by introducing deletion and substitution mutations in a truncated N-terminal...

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Identifiers

PMID: 21509658
DOI: 10.1007/s11427-011-4151-4

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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