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Article

Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription.

The Journal of biological chemistry - 1 Mar 2002

Kegel Kimberly B, Meloni Alison R, Yi Yong, Kim Yun J, Doyle Erin, Cuiffo Benjamin G, Sapp Ellen, Wang Yumei, Qin Zheng-Hong, Chen J Don, Nevins Joseph R, Aronin Neil, DiFiglia Marian

Abstract excerpt

Huntingtin is a protein of unknown function that contains a polyglutamine tract, which is expanded in patients with Huntington's disease (HD). We investigated the localization and a potential function for huntingtin in the nucleus. In human fibroblasts from normal and HD patients, huntingtin localized diffusely in the nucleus and in subnuclear compartments identified as speckles, promyelocytic leukemia protein...

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PMID: 11739372
DOI: 10.1074/jbc.M103946200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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