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Article

Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease.

Human molecular genetics - 15 Oct 2005

Benn Caroline L, Landles Christian, Li He, Strand Andrew D, Woodman Ben, Sathasivam Kirupa, Li Shi-Hua, Ghazi-Noori Shabnam, Hockly Emma, Faruque Syed M N N, Cha Jang-Ho J, Sharpe Paul T, Olson James M, Li Xiao-Jiang, Bates Gillian P

Abstract excerpt

In postmortem Huntington's disease brains, mutant htt is present in both nuclear and cytoplasmic compartments. To dissect the impact of nuclear and extranuclear mutant htt on the initiation and progression of disease, we generated a series of transgenic mouse lines in which nuclear localization or nuclear export signal sequences have been placed N-terminal to the htt exon 1 protein carrying 144 glutamines. Our...

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PMID: 16183657
DOI: 10.1093/hmg/ddi340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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