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Article

Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates.

Neuroscience - 1 Jan 2005

Willie J T, Renthal W, Chemelli R M, Miller M S, Scammell T E, Yanagisawa M, Sinton C M

Abstract excerpt

Narcolepsy-cataplexy, a disorder of excessive sleepiness and abnormalities of rapid eye movement (REM) sleep, results from deficiency of the hypothalamic orexin (hypocretin) neuropeptides. Modafinil, an atypical wakefulness-promoting agent with an unknown mechanism of action, is used to treat hypersomnolence in these patients. Fos protein immunohistochemistry has previously demonstrated that orexin neurons are...

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PMID: 15652995
DOI: 10.1016/j.neuroscience.2004.10.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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