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Article

Phospholipase C-beta4 is essential for the progression of the normal sleep sequence and ultradian body temperature rhythms in mice.

PloS one - 9 Nov 2009

Ikeda Masayuki, Hirono Moritoshi, Sugiyama Takashi, Moriya Takahiro, Ikeda-Sagara Masami, Eguchi Naomi, Urade Yoshihiro, Yoshioka Tohru

Abstract excerpt

BACKGROUND: THE SLEEP SEQUENCE: i) non-REM sleep, ii) REM sleep, and iii) wakefulness, is stable and widely preserved in mammals, but the underlying mechanisms are unknown. It has been shown that this sequence is disrupted by sudden REM sleep onset during active wakefulness (i.e., narcolepsy) in orexin-deficient mutant animals. Phospholipase C (PLC) mediates the signaling of numerous metabotropic receptors,...

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Share to Body Temperature
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Metabotropic Glutamate

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Source

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Identifiers

PMID: 19898623
DOI: 10.1371/journal.pone.0007737
PMCID: PMC2770323

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