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Article

How to keep the brain awake? The complex molecular pharmacogenetics of wake promotion.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2009

Hasan Sibah, Pradervand Sylvain, Ahnaou Abdellah, Drinkenburg Wilhelmus, Tafti Mehdi, Franken Paul

Abstract excerpt

Wake-promoting drugs are widely used to treat excessive daytime sleepiness. The neuronal pathways involved in wake promotion are multiple and often not well characterized. We tested d-amphetamine, modafinil, and YKP10A, a novel wake-promoting compound, in three inbred strains of mice. The wake duration induced by YKP10A and d-amphetamine depended similarly on genotype, whereas opposite strain differences were...

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Identifiers

PMID: 19194377
DOI: 10.1038/npp.2009.3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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