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Article

Abnormal sleep/wake dynamics in orexin knockout mice.

Sleep - 1 Mar 2010

Diniz Behn Cecilia G, Klerman Elizabeth B, Mochizuki Takatoshi, Lin Shih-Chieh, Scammell Thomas E

Abstract excerpt

STUDY OBJECTIVES: Narcolepsy with cataplexy is caused by a loss of orexin (hypocretin) signaling, but the physiologic mechanisms that result in poor maintenance of wakefulness and fragmented sleep remain unknown. Conventional scoring of sleep cannot reveal much about the process of transitioning between states or the variations within states. We developed an EEG spectral analysis technique to determine whether...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20337187
DOI: 10.1093/sleep/33.3.297
PMCID: PMC2831423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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