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Article

Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT.

Sleep - 1 Aug 2010

Bodenmann Sereina, Landolt Hans-Peter

Abstract excerpt

STUDY OBJECTIVES: Modafinil may promote wakefulness by increasing cerebral dopaminergic neurotransmission, which importantly depends on activity of catechol-O-methyltransferase (COMT) in prefrontal cortex. The effects of modafinil on sleep homeostasis in humans are unknown. Employing a novel sleep-pharmacogenetic approach, we investigated the interaction of modafinil with sleep deprivation to study dopaminergic...

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Source

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Identifiers

PMID: 20815183
DOI: 10.1093/sleep/33.8.1027
PMCID: PMC2910532

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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