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The homocysteine controversy

21 Jun 2010

Abstract excerpt

Mild to moderate hyperhomocysteinemia has been identified as a strong predictor of cardiovascular disease, independent from classical atherothrombotic risk factors. In the last decade, a number of large intervention trials using B vitamins have been performed and have shown no benefit of homocysteine-lowering therapy in high-risk patients. In addition, Mendelian randomization studies failed to convincingly...

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PMID: 20567905
DOI: 10.1007/s10545-010-9151-1

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