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MTHFR Polymorphisms, Homocysteine Elevation, and Ischemic Stroke Susceptibility in East Asian and European Populations

9 Jan 2025

Abstract excerpt

BACKGROUND AND OBJECTIVES: has been implicated in cerebrovascular disease risk, although research in diverse populations is lacking. We thus aimed to investigate the effect of genetically predicted MTHFR activity on risk of ischemic stroke (IS) and its main subtypes using a multiancestry Mendelian randomization (MR) approach. METHODS: We proxied reduced MTHFR function using the C677T missense variant that impairs...

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PMID: 39787475
DOI: 10.1212/wnl.0000000000210245

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