Article
Lack of interferon sensitivity-determining region in the genome of hepatitis B virus genotype Ba.
Antiviral therapy - 1 Dec 2004
Liu Chun-Jen, Chen Pei-Jer, Lai Ming-Yang, Chen Ting-Chih, Wang Hurng-Yi, Huang Wen-Ling, Kao Jia-Horng, Chen Ding-Shinn
Abstract excerpt
BACKGROUND/AIMS: In chronic hepatitis B, both host and viral factors may predict the response to interferon (IFN) treatment. Whether IFN sensitivity-determining regions exist within the hepatitis B virus (HBV) genomic background remains largely unknown. We therefore performed full-length viral genomic comparison between HBVs obtained from IFN responders and non-responders. METHODS: We enrolled 18 HBV genotype Ba...
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