Article
Number and position of mutations in the interferon (IFN) sensitivity-determining region of the gene for nonstructural protein 5A correlate with IFN efficacy in hepatitis C virus genotype 1b infection.
The Journal of infectious diseases - 15 Apr 2001
Watanabe H, Enomoto N, Nagayama K, Izumi N, Marumo F, Sato C, Watanabe M
Abstract excerpt
To explore the relationship between responses to interferon (IFN) and the mutation patterns in the IFN sensitivity-determining region (ISDR; amino acid positions 2209-2248) in the NS5A gene of hepatitis C virus genotype 1b, a cohort of 334 patients was analyzed. The number of mutations in the ISD...
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