Article
Conditional mutations in the mitotic chromosome binding function of the bovine papillomavirus type 1 E2 protein.
Journal of virology - 1 Feb 2005
Zheng Peng-Sheng, Brokaw Jane, McBride Alison A
Abstract excerpt
The papillomavirus E2 protein is required for viral transcriptional regulation, DNA replication and genome segregation. We have previously shown that the E2 transactivator protein and BPV1 genomes are associated with mitotic chromosomes; E2 links the genomes to cellular chromosomes to ensure efficient segregation to daughter nuclei. The transactivation domain of the E2 protein is necessary and sufficient for...
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