Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human papillomavirus (HPV) origin-binding protein associates with mitotic spindles to enable viral DNA partitioning

12 Mar 2004

Abstract excerpt

Human papillomaviruses (HPVs) establish long-term infections in patients. The mechanism for extrachromosomal HPV DNA persistence in cycling cells is unknown. We show that HPV origin-containing plasmids partition as minichromosomes, attributable to an association of the viral origin recognition protein E2 with mitotic spindles. alpha-, beta-, and gamma-tubulins were pulled down with a tagged E2. The N-terminal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cervical Cancer and HPV Research
Share to Hepatitis B Virus Studies
Share to Herpesvirus Infections and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15020762
DOI: 10.1073/pnas.0306848101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human papillomavirus (HPV) origin-binding protein associates with mitotic spindles to enable viral DNA partitioningPMID 15020762Read ↗

Dynamic Localization of the Human Papillomavirus Type 11 Origin Binding Protein E2 through Mitosis While in Association with the Spindle ApparatusSemantic proximity Read ↗

Interaction with TopBP1 Is Required for Human Papillomavirus 16 E2 Plasmid Segregation/Retention Function during MitosisSemantic proximity Read ↗

Partitioning Viral Genomes in Mitosis: Same Idea, Different TargetsSemantic proximity Read ↗

Variations in the association of papillomavirus E2 proteins with mitotic chromosomesSemantic proximity Read ↗

The Cellular DNA Helicase ChlR1 Regulates Chromatin and Nuclear Matrix Attachment of the Human Papillomavirus 16 E2 Protein and High-Copy-Number Viral Genome Establishment.Semantic proximity Read ↗

Conditional mutations in the mitotic chromosome binding function of the bovine papillomavirus type 1 E2 protein.Semantic proximity Read ↗

Interaction of the Betapapillomavirus E2 Tethering Protein with Mitotic ChromosomesSemantic proximity Read ↗

Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation functionSemantic proximity Read ↗

Human Papillomavirus Genome Copy Number Is Maintained by S-Phase Amplification, Genome Loss to the Cytosol during Mitosis, and Degradation in G 1 PhaseSemantic proximity Read ↗

A central region in the minor capsid protein of papillomaviruses facilitates viral genome tethering and membrane penetration for mitotic nuclear entry.Semantic proximity Read ↗

An Interaction between Human Papillomavirus 16 E2 and TopBP1 Is Required for Optimum Viral DNA Replication and Episomal Genome EstablishmentSemantic proximity Read ↗

E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.