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The Mitotic Chromosome Binding Activity of the Papillomavirus E2 Protein Correlates with Interaction with the Cellular Chromosomal Protein, Brd4

28 Mar 2005

Abstract excerpt

The papillomavirus transcriptional activator, E2, is involved in key functions of the viral life cycle. These include transcriptional regulation, viral DNA replication, and viral genome segregation. The transactivation domain of E2 is required for each of these functions. To identify the regions of the domain that mediate binding to mitotic chromosomes, a panel of mutations has been generated and their effect on...

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PMID: 15795266
DOI: 10.1128/jvi.79.8.4806-4818.2005

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Research trail→

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The Mitotic Chromosome Binding Activity of the Papillomavirus E2 Protein Correlates with Interaction with the Cellular Chromosomal Protein, Brd4PMID 15795266Read ↗

Conditional mutations in the mitotic chromosome binding function of the bovine papillomavirus type 1 E2 protein.Semantic proximity Read ↗

Brd4 Is Required for E2-Mediated Transcriptional Activation but Not Genome Partitioning of All PapillomavirusesSemantic proximity Read ↗

Interaction of the Betapapillomavirus E2 Tethering Protein with Mitotic ChromosomesSemantic proximity Read ↗

Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation functionSemantic proximity Read ↗

Phosphorylation of HPV-16 E2 at serine 243 enables binding to Brd4 and mitotic chromosomes.Semantic proximity Read ↗

Dimerization of the papillomavirus E2 protein is required for efficient mitotic chromosome association and Brd4 binding.Semantic proximity Read ↗

Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function.Semantic proximity Read ↗

Inhibition of E2 binding to Brd4 enhances viral genome loss and phenotypic reversion of bovine papillomavirus-transformed cells.Semantic proximity Read ↗

E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes.Semantic proximity Read ↗

Interaction with TopBP1 Is Required for Human Papillomavirus 16 E2 Plasmid Segregation/Retention Function during MitosisSemantic proximity Read ↗

Variations in the association of papillomavirus E2 proteins with mitotic chromosomesSemantic proximity Read ↗

The Human Papillomavirus Type 8 E2 Tethering Protein Targets the Ribosomal DNA Loci of Host Mitotic ChromosomesSemantic proximity Read ↗

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