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Article

Phosphorylation of HPV-16 E2 at serine 243 enables binding to Brd4 and mitotic chromosomes.

PloS one - 1 Jan 2014

Chang Szu-Wei, Liu Wei-Chen, Liao Kuan-Yu, Tsao Yeou-Ping, Hsu Pang-Hung, Chen Show-Li

Abstract excerpt

The papillomavirus E2 protein is involved in the maintenance of persistent infection and known to bind either to cellular factors or directly to mitotic chromosomes in order to partition the viral genome into the daughter cells. However, how the HPV-16 E2 protein acts to facilitate partitioning of the viral genome remains unclear. In this study, we found that serine 243 of HPV-16 E2, located in the hinge region,...

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Identifiers

PMID: 25340539
DOI: 10.1371/journal.pone.0110882
PMCID: PMC4207782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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