Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dimerization of the papillomavirus E2 protein is required for efficient mitotic chromosome association and Brd4 binding.

Journal of virology - 1 Aug 2008

Cardenas-Mora Juan, Spindler Jonathan E, Jang Moon Kyoo, McBride Alison A

Abstract excerpt

The E2 proteins of several papillomaviruses link the viral genome to mitotic chromosomes to ensure retention and the efficient partitioning of genomes into daughter cells following cell division. Bovine papillomavirus type 1 E2 binds to chromosomes in a complex with Brd4, a cellular bromodomain protein. Interaction with Brd4 is also important for E2-mediated transcriptional regulation. The transactivation domain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bovine papillomavirus 1
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomes

Share to Dimerization

Share to Nuclear Proteins

Share to Protein Interaction Domains and Motifs

Share to Protein Interaction Mapping

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18495759
DOI: 10.1128/JVI.00772-08
PMCID: PMC2493320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dimerization of the papillomavirus E2 protein is required for efficient mitotic chromosome association and Brd4 binding.PMID 18495759Read ↗

Brd4 Is Required for E2-Mediated Transcriptional Activation but Not Genome Partitioning of All PapillomavirusesSemantic proximity Read ↗

Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function.Semantic proximity Read ↗

The Mitotic Chromosome Binding Activity of the Papillomavirus E2 Protein Correlates with Interaction with the Cellular Chromosomal Protein, Brd4Semantic proximity Read ↗

Inhibition of E2 binding to Brd4 enhances viral genome loss and phenotypic reversion of bovine papillomavirus-transformed cells.Semantic proximity Read ↗

Conditional mutations in the mitotic chromosome binding function of the bovine papillomavirus type 1 E2 protein.Semantic proximity Read ↗

Abrogation of the Brd4-Positive Transcription Elongation Factor b Complex by Papillomavirus E2 Protein Contributes to Viral Oncogene RepressionSemantic proximity Read ↗

Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation functionSemantic proximity Read ↗

Brd4 Regulation of Papillomavirus Protein E2 StabilitySemantic proximity Read ↗

Evidence Supporting a Role for TopBP1 and Brd4 in the Initiation but Not Continuation of Human Papillomavirus 16 E1/E2-Mediated DNA ReplicationSemantic proximity Read ↗

Phosphorylation of HPV-16 E2 at serine 243 enables binding to Brd4 and mitotic chromosomes.Semantic proximity Read ↗

Interaction of the Betapapillomavirus E2 Tethering Protein with Mitotic ChromosomesSemantic proximity Read ↗

E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.