Article
E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes.
Journal of virology - 1 Apr 2002
Voitenleitner Christian, Botchan Michael
Abstract excerpt
Eukaryotic viruses can maintain latency in dividing cells as extrachromosomal plasmids. It is therefore of vital importance for viruses to ensure nuclear retention and proper segregation of their viral DNA. The bovine papillomavirus (BPV) E2 enhancer protein plays a key role in these processes by tethering the viral DNA to the host cell chromosomes. Viral genomes that harbor phosphorylation mutations in the E2...
Topics
- Alanine
- Amino Acid Substitution
- Animals
- Bovine papillomavirus 1
- Cell Line
- Chromosomes
- DNA Replication
- DNA, Viral
- DNA-Binding Proteins
- Mitosis
- Mutation
- Plasmids
- Protein Binding
- Repressor Proteins
- Transcription, Genetic
- Viral Proteins
- Virus Replication