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Brd4 Is Required for E2-Mediated Transcriptional Activation but Not Genome Partitioning of All Papillomaviruses

14 Sept 2006

Abstract excerpt

Bromodomain protein 4 (Brd4) has been identified as the cellular binding target through which the E2 protein of bovine papillomavirus type 1 links the viral genome to mitotic chromosomes. This tethering ensures retention and efficient partitioning of genomes to daughter cells following cell division. E2 is also a regulator of viral gene expression and a replication factor, in association with the viral E1...

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PMID: 16973557
DOI: 10.1128/jvi.01105-06

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Brd4 Is Required for E2-Mediated Transcriptional Activation but Not Genome Partitioning of All PapillomavirusesPMID 16973557Read ↗

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The Mitotic Chromosome Binding Activity of the Papillomavirus E2 Protein Correlates with Interaction with the Cellular Chromosomal Protein, Brd4Semantic proximity Read ↗

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The Human Papillomavirus Type 8 E2 Tethering Protein Targets the Ribosomal DNA Loci of Host Mitotic ChromosomesSemantic proximity Read ↗

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Analysis of chromatin attachment and partitioning functions of bovine papillomavirus type 1 E2 protein.Semantic proximity Read ↗

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Evidence Supporting a Role for TopBP1 and Brd4 in the Initiation but Not Continuation of Human Papillomavirus 16 E1/E2-Mediated DNA ReplicationSemantic proximity Read ↗

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