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Variations in the association of papillomavirus E2 proteins with mitotic chromosomes

13 Jan 2006

Abstract excerpt

The E2 protein segregates episomal bovine papillomavirus (BPV) genomes to daughter cells by tethering them to mitotic chromosomes, thus ensuring equal distribution and retention of viral DNA. To date, only the BPV1 E2 protein has been shown to bind to mitotic chromosomes. We assessed the localization of 13 different animal and human E2 proteins from seven papillomavirus genera, and we show that most of them are...

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PMID: 16415162
DOI: 10.1073/pnas.0507624103

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