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Article

Follistatin is a novel therapeutic target and biomarker in FLT3/ITD acute myeloid leukemia.

EMBO molecular medicine - 7 Apr 2020

He Bai-Liang, Yang Ning, Man Cheuk Him, Ng Nelson Ka-Lam, Cher Chae-Yin, Leung Ho-Ching, Kan Leo Lai-Hok, Cheng Bowie Yik-Ling, Lam Stephen Sze-Yuen, Wang Michelle Lu-Lu, Zhang Chun-Xiao, Kwok Hin, Cheng Grace, Sharma Rakesh, Ma Alvin Chun-Hang, So Chi Wai Eric, Kwong Yok-Lam, Leung Anskar Yu-Hung

Abstract excerpt

Internal tandem duplication of Fms-like tyrosine kinase 3 (FLT3/ITD) occurs in about 30% of acute myeloid leukemia (AML) and is associated with poor response to conventional treatment and adverse outcome. Here, we reported that human FLT3/ITD expression led to axis duplication and dorsalization in about 50% of zebrafish embryos. The morphologic phenotype was accompanied by ectopic expression of a morphogen...

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Identifiers

PMID: 32134197
DOI: 10.15252/emmm.201910895
PMCID: PMC7136967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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