Article
Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in FLT3-Mutant Acute Myeloid Leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2018
Jiang Xuejie, Mak Po Yee, Mu Hong, Tao Wenjing, Mak Duncan H, Kornblau Steven, Zhang Qi, Ruvolo Peter, Burks Jared K, Zhang Weiguo, McQueen Teresa, Pan Rongqing, Zhou Hongsheng, Konopleva Marina, Cortes Jorge, Liu Qifa, Andreeff Michael, Carter Bing Z
Abstract excerpt
Purpose: Wnt/β-catenin signaling is required for leukemic stem cell function. FLT3 mutations are frequently observed in acute myeloid leukemia (AML). Anomalous FLT3 signaling increases β-catenin nuclear localization and transcriptional activity. FLT3 tyrosine kinase inhibitors (TKI) are used clinically to treat FLT3-mutated AML patients, but with limited efficacy. We investigated the antileukemia activity of...
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