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Article

Directing oncogenic fusion genes into stem cells via an SCL enhancer.

Proceedings of the National Academy of Sciences of the United States of America - 25 Jan 2005

Eguchi Mariko, Eguchi-Ishimae Minenori, Green Anthony, Enver Tariq, Greaves Mel

Abstract excerpt

TEL-TRKC is a fusion gene generated by chromosomal translocation and encodes an activated tyrosine kinase. Uniquely, it is found in both solid tumors and leukemia. However, a single exon difference (in TEL) in TEL-TRKC fusions is associated with the two sets of cancer phenotypes. We expressed the two TEL-TRKC variants in vivo by using the 3' regulatory element of SCL that is selectively active in a subset of...

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Share to Blood Vessels
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hematopoiesis

Share to Hematopoietic Stem Cells

Share to Leukemia, Experimental

Share to Oncogene Proteins, Fusion

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Share to Vascular Endothelial Growth Factor Receptor-2

Source

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Identifiers

PMID: 15650051
DOI: 10.1073/pnas.0405318102
PMCID: PMC545834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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