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Article

Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.

Journal of the National Cancer Institute. Monographs - 1 Jan 2008

Lobato M Natividad, Metzler Markus, Drynan Lesley, Forster Alan, Pannell Richard, Rabbitts Terence H

Abstract excerpt

Recurrent reciprocal chromosomal translocations are present in more than 50% of leukemias. A deeper understanding of how they affect cancer initiation is essential for evaluating the origins of cancer and the potential for therapy based on the translocation products. Mouse models of chromosomal translocations are required for this. Here we summarize three methodologies developed in our laboratory to model...

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Identifiers

PMID: 18648005
DOI: 10.1093/jncimonographs/lgn022

Genes

ERG

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