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Article

Identification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia.

Molecular and cellular biology - 1 Dec 2000

Reuther G W, Lambert Q T, Caligiuri M A, Der C J

Abstract excerpt

In this study, we utilized retroviral transfer of cDNA libraries in order to identify oncogenes that are expressed in acute myeloid leukemia (AML). From screens using two different cell types as targets for cellular transformation, a single cDNA encoding a variant of the TrkA protooncogene was isolated. The protein product of this protooncogene, TrkA, is a receptor tyrosine kinase for nerve growth factor. The...

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Identifiers

PMID: 11073967
DOI: 10.1128/MCB.20.23.8655-8666.2000
PMCID: PMC86471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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