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Article

Tel, a frequent target of leukemic translocations, induces cellular aggregation and influences expression of extracellular matrix components.

Neoplasia (New York, N.Y.) - 1 Dec 1999

Van Rompaey L, Dou W, Buijs A, Grosveld G

Abstract excerpt

Tel is an Ets transcription factor that is the target of chromosome translocations in lymphoid and myeloid leukemias and in solid tumors. It contains two functional domains, a pointed oligomerization domain and a DNA-binding domain. Retroviral transduction of a wild-type Tel cDNA into a clonal subline of NIH3T3 fibroblasts resulted in a striking morphologic change: at confluency, the cells reorganized into a...

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Share to 3T3 Cells
Share to Cell Aggregation
Share to ETS Translocation Variant 6 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-ets

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Source

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Identifiers

PMID: 10935500
DOI: 10.1038/sj.neo.7900064
PMCID: PMC1679818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tel, a frequent target of leukemic translocations, induces cellular aggregation and influences expression of extracellular matrix components.PMID 10935500Read ↗

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