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Article

The ets Family Member Tel Binds to the Fli-1 Oncoprotein and Inhibits Its Transcriptional Activity

1 Jul 1998

Abstract excerpt

The tel gene, recently shown to be translocated in a spectrum of acute and chronic human leukemias, belongs to the ets family of sequence-specific transcription factors. To determine the role of Tel in normal hematopoietic development, we used the tel gene as the bait in the yeast two-hybrid system to screen a hematopoietic stem cell library. Two partners were identified: Tel binds to itself, and Tel binds to the...

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PMID: 9651344
DOI: 10.1074/jbc.273.28.17525

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Related research

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Research trail→

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The ets Family Member Tel Binds to the Fli-1 Oncoprotein and Inhibits Its Transcriptional ActivityPMID 9651344Read ↗

TEL Is a Sequence-specific Transcriptional RepressorSemantic proximity Read ↗

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ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancerSemantic proximity Read ↗

Oligomerization of the ABL Tyrosine Kinase by the Ets Protein TEL in Human LeukemiaSemantic proximity Read ↗

Defining the oncogenic function of the TEL/AML1 (ETV6/RUNX1) fusion protein in a mouse model.Semantic proximity Read ↗

Initially disadvantaged, TEL-AML1 cells expand and initiate leukemia in response to irradiation and cooperating mutationsSemantic proximity Read ↗

A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human LeukemiaSemantic proximity Read ↗

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