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Article

Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.

Proceedings of the National Academy of Sciences of the United States of America - 9 Apr 2013

Tang Jian Zhong, Carmichael Catherine L, Shi Wei, Metcalf Donald, Ng Ashley P, Hyland Craig D, Jenkins Nancy A, Copeland Neal G, Howell Viive M, Zhao Zhizhuang Joe, Smyth Gordon K, Kile Benjamin T, Alexander Warren S

Abstract excerpt

To define genetic lesions driving leukemia, we targeted cre-dependent Sleeping Beauty (SB) transposon mutagenesis to the blood-forming system using a hematopoietic-selective vav 1 oncogene (vav1) promoter. Leukemias of diverse lineages ensued, most commonly lymphoid leukemia and erythroleukemia. The inclusion of a transgenic allele of Janus kinase 2 (JAK2)V617F resulted in acceleration of transposon-driven...

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Share to Gene Expression Regulation, Leukemic
Share to Leukemia, Erythroblastic, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Megakaryoblastic, Acute

Share to Neoplasm Transplantation

Share to Oncogene Proteins

Share to Proto-Oncogene Protein c-ets-1

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Share to Transcriptional Regulator ERG

Source

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Identifiers

PMID: 23533276
DOI: 10.1073/pnas.1304234110
PMCID: PMC3625293

Genes

ERG
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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