Article
Effects of lipoprotein lipase on uptake and transcytosis of low density lipoprotein (LDL) and LDL-associated alpha-tocopherol in a porcine in vitro blood-brain barrier model.
The Journal of biological chemistry - 9 Aug 2002
Goti Daniel, Balazs Zoltan, Panzenboeck Ute, Hrzenjak Andelko, Reicher Helga, Wagner Elke, Zechner Rudolf, Malle Ernst, Sattler Wolfgang
Abstract excerpt
During the present study the contribution of lipoprotein lipase (LPL) to low density lipoprotein (LDL) holoparticle and LDL-lipid (alpha-tocopherol (alphaTocH)) turnover in primary porcine brain capillary endothelial cells (BCECs) was investigated. The addition of increasing LPL concentrations to BCECs resulted in up to 11-fold higher LDL holoparticle cell association. LPL contributed to LDL holoparticle...
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