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Article

Involvement of Sir2/4 in silencing of DNA breakage and recombination on mouse YACs during yeast meiosis.

Molecular biology of the cell - 1 Mar 2005

Klieger Yair, Yizhar Ofer, Zenvirth Drora, Shtepel-Milman Neta, Snoek Margriet, Simchen Giora

Abstract excerpt

Yeast artificial chromosomes (YACs) that contain human DNA backbone undergo DNA double-strand breaks (DSBs) and recombination during yeast meiosis at rates similar to the yeast native chromosomes. Surprisingly, YACs containing DNA covering a recombination hot spot in the mouse major histocompatibility complex class III region do not show meiotic DSBs and undergo meiotic recombination at reduced levels. Moreover,...

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Identifiers

PMID: 15647382
DOI: 10.1091/mbc.e04-07-0592
PMCID: PMC551506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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