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Article

Lipoprotein-heparan sulfate interactions in the Hh pathway.

Developmental cell - 1 Jul 2007

Eugster Christina, Panáková Daniela, Mahmoud Ali, Eaton Suzanne

Abstract excerpt

The Drosophila lipoprotein particle, Lipophorin, bears lipid-linked morphogens on its surface and is required for long-range signaling activity of Wingless and Hedgehog. Heparan sulfate proteoglycans are also critical for trafficking and signaling of these morphogens. Here we show that Lipophorin interacts with the heparan sulfate moieties of the glypicans Dally and Dally-like. Membrane-associated glypicans can...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17609110
DOI: 10.1016/j.devcel.2007.04.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lipoprotein-heparan sulfate interactions in the Hh pathway.PMID 17609110Read ↗

Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling.Semantic proximity Read ↗

Glypicans shield the Wnt lipid moiety to enable signalling at a distance.Semantic proximity Read ↗

Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity.Semantic proximity Read ↗

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila.Semantic proximity Read ↗

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling.Semantic proximity Read ↗

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Regulation of dally, an integral membrane proteoglycan, and its function during adult sensory organ formation of Drosophila.Semantic proximity Read ↗

Crossveinless d is a vitellogenin-like lipoprotein that binds BMPs and HSPGs, and is required for normal BMP signaling in the Drosophila wing.Semantic proximity Read ↗

Developmental roles of heparan sulfate proteoglycans in Drosophila.Semantic proximity Read ↗

The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors.Semantic proximity Read ↗

The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog.Semantic proximity Read ↗

Glypicans shunt the Wingless signal between local signalling and further transport.Semantic proximity Read ↗

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