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Article

Peroxisome proliferator-activated receptor-binding protein null mutation results in defective mammary gland development.

The Journal of biological chemistry - 18 Mar 2005

Jia Yuzhi, Qi Chao, Zhang Zhongyi, Zhu Yiwei Tony, Rao Sambasiva M, Zhu Yi-Jun

Abstract excerpt

A conditional null mutation of peroxisome proliferator-activated receptor-binding protein (PBP) gene was generated to understand its role in mammary gland development. PBP-deficient mammary glands exhibited retarded ductal elongation during puberty, and decreased alveolar density during pregnancy and lactation. PBP-deficient mammary glands could not produce milk to nurse pups during lactation. Both the mammary...

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PMID: 15647257
DOI: 10.1074/jbc.M413331200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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