Article
PEX11alpha is required for peroxisome proliferation in response to 4-phenylbutyrate but is dispensable for peroxisome proliferator-activated receptor alpha-mediated peroxisome proliferation.
Molecular and cellular biology - 1 Dec 2002
Li Xiaoling, Baumgart Eveline, Dong Gao-Xiang, Morrell James C, Jimenez-Sanchez Gerardo, Valle David, Smith Kirby D, Gould Stephen J
Abstract excerpt
The PEX11 peroxisomal membrane proteins promote peroxisome division in multiple eukaryotes. As part of our effort to understand the molecular and physiological functions of PEX11 proteins, we disrupted the mouse PEX11alpha gene. Overexpression of PEX11alpha is sufficient to promote peroxisome division, and a class of chemicals known as peroxisome proliferating agents (PPAs) induce the expression of PEX11alpha and...
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