Article
PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation.
Cancer research - 15 Jul 2013
Yuan Hongyan, Lu Jin, Xiao Junfeng, Upadhyay Geeta, Umans Rachel, Kallakury Bhaskar, Yin Yuhzi, Fant Michael E, Kopelovich Levy, Glazer Robert I
Abstract excerpt
The peroxisome proliferator-activated receptor-δ (PPARδ) regulates a multitude of physiological processes associated with glucose and lipid metabolism, inflammation, and proliferation. One or more of these processes are potential risk factors for the ability of PPARδ agonists to promote tumorigenesis in the mammary gland. In this study, we describe a new transgenic mouse model in which activation of PPARδ in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.