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Article

Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice.

Developmental biology - 1 Jul 2014

Vapola Miia H, Rokka Aare, Sormunen Raija T, Alhonen Leena, Schmitz Werner, Conzelmann Ernst, Wärri Anni, Grunau Silke, Antonenkov Vasily D, Hiltunen J Kalervo

Abstract excerpt

To understand the functional role of the peroxisomal membrane channel Pxmp2, mice with a targeted disruption of the Pxmp2 gene were generated. These mice were viable, grew and bred normally. However, Pxmp2(-/-) female mice were unable to nurse their pups. Lactating mammary gland epithelium displayed secretory lipid droplets and milk proteins, but the size of the ductal system was greatly reduced. Examination of...

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PMID: 24726525
DOI: 10.1016/j.ydbio.2014.03.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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