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Article

CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence.

Infection and immunity - 1 Mar 2004

Noverr Mairi C, Williamson Peter R, Fajardo Ryan S, Huffnagle Gary B

Abstract excerpt

The pathogenic yeast Cryptococcus neoformans produces a laccase enzyme (CNLAC1), which catalyzes the synthesis of melanin in the presence of phenolic compounds. A number of genes have been implicated in the regulation of laccase and melanization, including IPC1, GPA1, MET3, and STE12. Albino mutants derived from random mutagenesis techniques may contain mutations in genes that regulate multiple virulence factors,...

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Identifiers

PMID: 14977977
DOI: 10.1128/IAI.72.3.1693-1699.2004
PMCID: PMC356011

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Source receipt: pubmed, retrieved 7 Sept 2026.

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