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The interplay between electron transport chain function and iron regulatory factors influences melanin formation in <i>Cryptococcus neoformans</i>

2024-02-18

Abstract excerpt

Mitochondrial functions are critical for the ability of the fungal pathogen Cryptococcus neoformans to cause disease. However, mechanistic connections between key functions such as the mitochondrial electron transport chain (ETC) and virulence factor elaboration have yet to be thoroughly characterized. Here, we observed that inhibition of ETC complex III suppressed melanin formation, a major virulence factor. Thi...

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Literature Corpus work
adda52ad-0d51-5235-b12a-bf8b80a5fbe4
DOI
10.1101/2024.02.15.580540
Open publication

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