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Article

Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade.

Eukaryotic cell - 1 Jan 2005

Pukkila-Worley Read, Gerrald Quincy D, Kraus Peter R, Boily Marie-Josée, Davis Matthew J, Giles Steven S, Cox Gary M, Heitman Joseph, Alspaugh J Andrew

Abstract excerpt

Cryptococcus neoformans is an opportunistic human fungal pathogen that elaborates several virulence attributes, including a polysaccharide capsule and melanin pigments. A conserved Galpha protein/cyclic AMP (cAMP) pathway controls melanin and capsule production. To identify targets of this pathway, we used an expression profiling approach to define genes that are transcriptionally regulated by the Galpha protein...

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Source

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Identifiers

PMID: 15643074
DOI: 10.1128/EC.4.1.190-201.2005
PMCID: PMC544166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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