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Article

Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth.

Eukaryotic cell - 1 Jan 2005

Giles Steven S, Batinic-Haberle Ines, Perfect John R, Cox Gary M

Abstract excerpt

Manganese superoxide dismutase is an essential component of the mitochondrial antioxidant defense system of most eukaryotes. In the present study, we used a reverse-genetics approach to assess the contribution of the Cryptococcus neoformans manganese superoxide dismutase (Sod2) for antioxidant defense. Strains with mutations in the SOD2 gene exhibited increased susceptibility to oxidative stress as well as poor...

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Identifiers

PMID: 15643059
DOI: 10.1128/EC.4.1.46-54.2005
PMCID: PMC544162

Genes

SOD2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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