Article
Relationship between superoxide dismutase and melanin in a pathogenic fungus.
Infection and immunity - 1 Sept 1994
Jacobson E S, Jenkins N D, Todd J M
Abstract excerpt
Since melanin is considered a virulence factor in Cryptococcus neoformans, its suppression at 37 degrees C has been perplexing. We now show an opposite thermal regulation of superoxide dismutase (SOD), consistent with a compensatory mechanism. Moreover, we demonstrate normal SOD and catalase levels in albino, oxygen-sensitive mutants. These results suggest that melanin is an antioxidant factor comparable in...
Topics
- Cryptococcus neoformans
- Melanins
- Monophenol Monooxygenase
- Mutation
- Superoxide Dismutase
- Temperature